1、Y950115分類號：R7379福建醫(yī)科大學(xué)碩士學(xué)位論文學(xué)校代碼：10392學(xué)號：Plkl、Raf1和Ki一67在胃癌中表達的研究SmdyonPlkl，RafIandKi67ExpressioninGastricCancer接收院(系)：申請人：學(xué)科(專業(yè))：導(dǎo)師：研究起止日期：福建醫(yī)科大學(xué)第一臨床學(xué)院陳壯威外科學(xué)(普外)戴起寶主任醫(yī)師蘭斌副主任醫(yī)師2004年5月至2005年11月二00六年一月StudyonPlkl，RaGlandKi

2、67ExpressioninGastricCancerObjective：Method：Results：AbstractToinvestigateexpressionofplkl、raf1andKi一67ingastriccancerandtheirrelationships；analyserelationshipbetweentheirexpressionsandclincoit’athologicalparametersImmtmo

3、histochemicaltechniquesareemployedtodetectexpressionofplkl、raf1andKi一67in80casesofhumangastriccancerand15easesofnormalgastrictissuesOThepositiveratesofplkl、raf1andKi67expressionsingastriccancertissueswere825％(66／80)，8125

4、％(65／80)and80％(64／80)respectivelywhiletheplkl、raf1andKi一67expressionin15normalgastrictissuesallshowednegative②Theexpressionofplklingastriccancerwassignificantlycorrelatedwithdepthoftumorinvasion，TNMstage，andlymphnodemeta

5、stasis(p(005)butnotwithotherparameters③Theexpressionofmf1ingastriccancerwassignificantlycorrelatedwithdepthoftumorinvasion，TNMstage，andlymphnodemetastasis(p005)butnotwithotherparameters④TheexpressionofKi一67ingastriccance

6、rwassignificantlycorrelated訊也histologicaldifferentiation，depthoftumorinvasion，TNMstage，andlymphnodemetastasis(pO01)butnotwithotherparameters，⑤Therelationshipsbetweenplklandraf1，rafIandKi67，plklandKi一67expressionweresigni